GLUTATHIONE AND PARKINSON’S DISEASE
Parkinson’s Disease is one of the several diseases in which glutathione may play an important role. Many of the things which have been suggested as possible causes of Parkinson’s Disease (including pesticides, iron, copper, zinc, manganese, mercury, lead, aluminum, and certain food borne toxins) are all oxidative stressors which deplete glutathione levels in the substantia nigra of the brain. A theory has been proposed that low levels of glutathione put people at greater risk for developing Parkinson’s. Experiments in administering glutathione to newly diagnosed patients produce striking improvement in function. When given 600 mg twice a day for 30 days patients showed an average of 42% decline in disability.
GLUTATHIONE AND CANCER
Glutathione prevents cancer, protecting DNA from damage by detoxifying harmful chemicals and removing them from the body. Low glutathione levels predispose people to cancer. Patients with a variety of malignant disorders were found to have a markedly lowered plasma glutathione level.
Glutathione also fights cancer. It selectively stimulates apoptosis (cell death) of malignant cells while leaving healthy cells unaffected. It does this by regulating the tumor suppressor protein p53. Under normal conditions, the p53 protein senses DNA damage in a cell and slows the rate of cell division, giving the cell time to repair itself. If the DNA cannot be repaired, p53 tells the cell to kill itself (apoptosis). Treatment with glutathione may reverse the cancer development process. Various studies have shown glutathione reverses development of neuroblastoma, cervical carcinoma, leukemia, and other cancers.
It also seems useful to combine glutathione with certain chemotherapy drugs, especially cisplatin, cyclophosphamide, and bleomycin. Glutathione decreases the toxic side effects of these drugs while either not affecting or increasing their therapeutic effect. Glutathione also protects against nerve damage when using cisplatin to treat gastric or ovarian cancer. Ovarian cancer frequently responds to chemotherapy treatment in a dose dependent manner, but toxic side effects frequently limit the amounts given. Using glutathione in conjunction with chemotherapy and radiation allows the use of higher, more effective drug levels, while reducing unwanted side effects.
GLUTATHIONE AND AUTISM
Children who are developing neuro typically are able to remove toxins like heavy metals, pesticides, and chemicals more effectively from the body. A developing child, for example, will use up two molecules of glutathione to get rid of one molecule of mercury. However, research shows that children with ASD and ADHD have impaired detoxification pathways. Children with autism have less glutathione, so it gets depleted more quickly, especially when there is a higher degree of environmental insult. Proximity to toxic landfills has consistently been associated with elevated rates of autism and developmental delay.
The key to effectively deal with autism is to address it early. Dr. Abellera has found that raising the glutathione level in children has shown improvement in speech, ability to focus, and a decrease in tantrums.
*INDIVIDUAL RESULTS MAY VARY.